Hemostasis and pathological thrombus formation are dynamic processes that require a co-
ordinated series of events involving platelet membrane receptors, bidirectional intracellular …

The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental
factors related to atherosclerosis and thrombosis. Acute thrombosis at the site of a ruptured …

Anti-platelet drug therapy is currently performed without monitoring, because the established
method of platelet aggregometry is cumbersome. The recently developed platelet function …

Objectives: We investigated whether three platelet gene polymorphisms, PlA1/A2, C807T,
and C-5T Kozak (encoding, respectively, for platelet membrane glycoproteins (GP) IIIa, GP …

Background and Purpose—The widespread use of aspirin requires clarification of the
aspirin resistance phenomenon. Most studies on this field are focused on patients which …

Thrombosis is the most important underlying mechanism of coronary artery disease and
embolic stroke. Hence, antithrombotic therapy is widely used in these scenarios. However …

Protease-activated receptor 1 (PAR-1), the main thrombin receptor on vascular cells, plays a
key role in platelet activation. We examined the range of PAR-1 expression on platelets …

Extracellular collagens modulate the rate of platelet activation and thereby markedly
influence hemostasis and thrombosis. Platelet receptors for collagens, such as the integrin …

The pregnancy-specific condition pre-eclampsia not only affects the health of mother and
baby during pregnancy but also has long-term consequences, increasing the chances of …

Stroke is one of the most common causes of death and long term disability throughout the
world. It may be the outcome of a number of monogenic disorders or, more commonly, a …