The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation
LJ Sweetlove, AR Fernie - Nature communications, 2018 - nature.com
Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …
Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces
L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
Metabolic highways may be orchestrated by the assembly of sequential enzymes into
protein complexes, or metabolons, to facilitate efficient channeling of intermediates and to …
protein complexes, or metabolons, to facilitate efficient channeling of intermediates and to …
Formation of flavonoid metabolons: functional significance of protein-protein interactions and impact on flavonoid chemodiversity
T Nakayama, S Takahashi, T Waki - Frontiers in Plant Science, 2019 - frontiersin.org
Flavonoids are a class of plant specialized metabolites with more than 6,900 known
structures and play important roles in plant survival and reproduction. These metabolites are …
structures and play important roles in plant survival and reproduction. These metabolites are …
The phenylpropanoid case–it is transport that matters
W Biała, M Jasiński - Frontiers in Plant Science, 2018 - frontiersin.org
Phenylpropanoids fulfill numerous physiological functions, essential for plant growth and
development, as well as plant–environment interactions. Over the last few decades, many …
development, as well as plant–environment interactions. Over the last few decades, many …
Protein-protein interactions and metabolite channelling in the plant tricarboxylic acid cycle
Y Zhang, KFM Beard, C Swart, S Bergmann… - Nature …, 2017 - nature.com
Protein complexes of sequential metabolic enzymes, often termed metabolons, may permit
direct channelling of metabolites between the enzymes, providing increased control over …
direct channelling of metabolites between the enzymes, providing increased control over …
Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories
Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant
specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of …
specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of …
A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol …
Withania somnifera produces pharmacologically important triterpenoid withanolides that are
derived via phytosterol pathway; however, their biosynthesis and regulation remain to be …
derived via phytosterol pathway; however, their biosynthesis and regulation remain to be …
Phenolamides in plants: An update on their function, regulation, and origin of their biosynthetic enzymes
Phenolamides represent a family of specialized metabolites, consisting of the association of
hydroxycinnamic acid derivatives with aliphatic or aromatic amines. Since the discovery of …
hydroxycinnamic acid derivatives with aliphatic or aromatic amines. Since the discovery of …
Phenylpropanoids accumulation in eggplant fruit: characterization of biosynthetic genes and regulation by a MYB transcription factor
Phenylpropanoids are major secondary metabolites in eggplant (Solanum melongena)
fruits. Chlorogenic acid (CGA) accounts for 70–90% of total phenolics in flesh tissues, while …
fruits. Chlorogenic acid (CGA) accounts for 70–90% of total phenolics in flesh tissues, while …