The post-GWAS era: from association to function
MD Gallagher, AS Chen-Plotkin - The American Journal of Human …, 2018 - cell.com
During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
Genome‐wide association studies on the phyllosphere microbiome: embracing complexity in host–microbe interactions
Environmental sequencing shows that plants harbor complex communities of microbes that
vary across environments. However, many approaches for mapping plant genetic variation …
vary across environments. However, many approaches for mapping plant genetic variation …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride …
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified>
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …
A linear mixed-model approach to study multivariate gene–environment interactions
R Moore, FP Casale, M Jan Bonder, D Horta… - Nature …, 2019 - nature.com
Different exposures, including diet, physical activity, or external conditions can contribute to
genotype–environment interactions (G× E). Although high-dimensional environmental data …
genotype–environment interactions (G× E). Although high-dimensional environmental data …
Cohort profile: the Singapore multi-ethnic cohort (mec) study
KHX Tan, LWL Tan, X Sim, ES Tai… - International journal …, 2018 - academic.oup.com
Non-communicable diseases such as type 2 diabetes (T2D) mellitus, coronary artery
disease, stroke and cancers, are major contributors to ill health across the world including …
disease, stroke and cancers, are major contributors to ill health across the world including …
Localization of adaptive variants in human genomes using averaged one-dependence estimation
Statistical methods for identifying adaptive mutations from population genetic data face
several obstacles: assessing the significance of genomic outliers, integrating correlated …
several obstacles: assessing the significance of genomic outliers, integrating correlated …
Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease
T Morimoto, Y Mineharu, K Ono, M Nakatochi… - PLoS one, 2017 - journals.plos.org
Background The genetic architecture of coronary artery disease has not been fully
elucidated, especially in Asian countries. Moyamoya disease is a progressive …
elucidated, especially in Asian countries. Moyamoya disease is a progressive …
Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: gaps and open questions
Aim Critically discuss the available data, to identify the current gaps and to provide key
concepts that will help clinicians in translating the biology of adipokines in the context of …
concepts that will help clinicians in translating the biology of adipokines in the context of …
Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of obesity-related traits
Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are
caused by an interchange between environmental and genetic factors. Recently, a number …
caused by an interchange between environmental and genetic factors. Recently, a number …