DV Shevyrev, VP Tereshchenko… - International Journal of …, 2022 - mdpi.com
The interaction of the T-cell receptor (TCR) with a peptide in the major histocompatibility complex (pMHC) plays a central role in the adaptive immunity of higher chordates. Due to …
On the T-cell surface the TCR is the only molecule that senses antigen, and the engagement of TCR with its specific antigenic peptide (agonist)/MHC complex (pMHC) is determined by …
JVS Ormonde, Y Nie, J Madrenas - Critical Reviews™ in …, 2019 - dl.begellhouse.com
Signaling from the T cell receptor for antigen turns on the physiological response of a T cell. The canonical TCR signaling pathway relies on early activation of the Src kinase LCK. This …
EV Nikolaev, A Zloza, ED Sontag - Frontiers in immunology, 2019 - frontiersin.org
It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in …
Canonical signaling from the T cell receptor triggers the physiological response of a T cell. The canonical TCR signaling pathway relies on activation of the Src kinase LCK, which is …
Abstract The recognition of Major Histocompatibility Complexes presenting linear peptides by T-Cell receptors is a key event in adaptive immunity. These interactions are MHC …