Biomechanical changes to the collagen fibrillar architecture in articular cartilage are
believed to play a crucial role in enabling normal joint function. However, experimentally …

Background Intervertebral disc (IVD) shows aging and degenerative changes earlier than
any other body connective tissue. Its repair and regeneration provide a considerable …

The development of biomimetic scaffolds containing cartilage, calcified cartilage, and bone
regeneration for precise osteochondral repair remains a challenge. Herein, a novel tri …

Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no
effective treatments are currently available. Arterial hypertension is a common comorbidity in …

Physiological mechanical stimulation has been shown to promote chondrogenesis, but
excessive mechanical loading results in cartilage degradation. Currently, the underlying …

The relationships between structure and function in human knee femoral cartilage are not
well-known at different stages of osteoarthritis. Thus, our aim was to characterize the depth …

Abnormal loading of the knee due to injuries or obesity is thought to contribute to the
development of osteoarthritis (OA). Small animal models have been used for studying OA …

Type 2 diabetes mellitus (T2D) is one of the prominent risk factors for the development and
progression of calcific aortic valve disease. Nevertheless, little is known about molecular …

Brachycephalic airway syndrome (BAS) is a well-established cause of respiratory distress in
dogs. BAS without surgical correction results in eventual laryngeal collapse. Arytenoid …

Abstract Background Estrogen deficiency and Diabetes mellitus (DM) cause joint tissue
deterioration, although the mechanisms are uncertain. This study evaluated the …