Herein we report a method for converting para-substituted pyridine rings into meta-
dialkylamino-substituted benzene rings through sequential ring-opening and ring-closing …

The thermal pericyclic cascade rearrangement of Zincke aldehydes (5-(dialkylamino)-2, 4-
pentadienals) to afford Z-α, β, γ, δ-unsaturated amides discovered by the Vanderwal group …

Hexatriene electrocyclization, if not disfavored by its harsh reaction conditions, can be highly
useful for the synthesis of complex organic molecules. Herein we developed a two-layer …

A benzene ring was formed to connect a carbonyl group of various methyl ketones with a π-
conjugated group through a p-phenylene linker. Methyl ketones and streptocyanines were …

Abstract On October 5, 1981, Fortune magazine published a cover article entitled the “Next
Industrial Revolution: Designing Drugs by Computer at Merck”. With a 40+ year investment …

Carbohydrate‐based benzylidene acetals undergo reductive ring opening. 1‐β‐O‐Acyl
glucoside conjugates of phenylacetic acids have been synthesized, and their acyl migration …

Electrocyclizations of 1, 3, 5-hexatrienes containing up to four electron-donating and/or
electron withdrawing substituents have been studied computationally using the hybrid …

A one-pot three-component synthesis of substituted meta-hetarylanilines from heterocycle-
substituted 1, 3-diketones has been developed. The electron-withdrawing power of the …

The olefin cross-metathesis reaction allows rapid access to 1, 5-dicarbonyl intermediates
which, upon treatment with a primary or secondary amine, allow the synthesis of a range of …

An unprecedented 6π‐electrocyclization–aromatization cascade reaction of ynedienamines
is described. The electron‐rich ynedienamine is converted by γ‐protonation to an …