Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

Importance To date, the association of psychiatric diagnoses with mortality in patients
infected with coronavirus disease 2019 (COVID-19) has not been evaluated. Objective To …

More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

Schizophrenia, a multisystem disorder with an unknown etiology, is associated with several
immune dysfunctions, including abnormal levels of circulating cytokines. In this review, we …

Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia's strongest genetic association at a population level involves variation in the …

The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …