Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

Blood malignancies provide unique opportunities for longitudinal tracking of disease
evolution following therapeutic bottlenecks and for the monitoring of changes in anti-tumor …

Stromal Antigen 1 and 2 (STAG1/2) are key subunits of the cohesin complex that mediate
sister chromatid cohesion, DNA repair, transcriptional regulation, and genome topology …

Epigenetic regulation is essential for the maintenance of the hematopoietic system, and its
deregulation is implicated in hematopoietic disorders. In this study, UTX, a demethylase for …

The strongest predictors of outcome in pediatric B‐cell precursor acute lymphoblastic
leukemia (BCP‐ALL) are minimal residual disease (MRD) and specific molecular …

Acute lymphoblastic leukemia (ALL) is a malignant clonal expansion of lymphoid
hematopoietic precursors that exhibit developmental arrest at varying stages of …

Rearrangement of the 1q12 pericentromeric heterochromatin and subsequent amplification
of the 1q arm is commonly associated with cancer development and progression and may …

Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that
has an orthologue on the Y chromosome (Uty)(Zheng et al. 2018). We previously identified …

Simple Summary Acute lymphoblastic leukemia is a heterogeneous disease characterized
by a diversity of genetic alterations, following a sophisticated and controversial organization …

The ETS transcription factors regulate expression of genes involved in normal cell
development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 …