Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic
retinopathy, and glaucoma, result in life-long functional deficits and enormous global health …

Regenerative medicine strategies rely on exogenous cell transplantation and/or
endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of …

Induced neural stem cells (iNSCs) reprogrammed from somatic cells have great potentials in
cell replacement therapies and in vitro modeling of neural diseases. Direct conversion of …

Activation of axonal growth program is a critical step in successful optic nerve regeneration
following injury. Yet the molecular mechanisms that orchestrate this developmental …

Following the fast pace of the growing field of stem cell research, retinal cell replacement is
finally emerging as a feasible mean to be explored for clinical application. Although …

Molecular information on the early stages of human retinal development remains scarce due
to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal …

Being part of the mature mammalian central nervous system, impairments of the retina and
optic nerves caused by trauma or diseases often cannot be restored. Progressive …

Glaucoma is a major global health concern and the leading cause of irreversible blindness
worldwide, characterized by the progressive degeneration of retinal ganglion cells (RGCs) …

Glaucoma is a group of irreversible blinding eye diseases characterized by the progressive
loss of retinal ganglion cells (RGCs) and their axons. Currently, there is no effective method …

Purpose: Currently, the only available and approved treatments for glaucoma are various
pharmacologic, laser-based, and surgical procedures that lower IOP. Although these …