Accumulating evidence has linked G-quadruplex structures to a number of biological
processes in vivo, including DNA replication, transcription, and genomic maintenance …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

Of the current next-generation sequencing technologies, SMRT sequencing is sometimes
overlooked. However, attributes such as long reads, modified base detection and high …

G-quadruplexes are guanine-rich nucleic acids that fold by forming successive quartets of
guanines (the G-tetrads), stabilized by intra-quartet hydrogen bonds, inter-quartet stacking …

Guanine-rich human telomeric DNA can adopt secondary structures known as G-
quadruplexes, which can be targeted by small molecules to achieve anticancer effects. So …

Terminal base pairs of DNA and RNA molecules in solution are known to undergo frequent
transient opening events (fraying). Accurate modeling of this process is important because of …

Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …

Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other
nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA …

We provide theoretical predictions of the intrinsic stability of different arrangements of
guanine quadruplex (G-DNA) stems. Most computational studies of nucleic acids have …

The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-
quadruplexes can be suitable drug targets and many small molecules have been identified …