Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

Mitochondria are cellular organelles essential for energy metabolism and antioxidant
defense. Mitochondrial impairment is implicated in many psychiatric disorders, including …

The chronic unpredictable mild stress model of depression has been widely used as an
experimental tool to investigate human psychopathology. Our objective was to provide an …

Background Depressed patients present increased plasma levels of lipopolysaccharide
(LPS) and neuroinflammatory alterations. Here, we determined the neuroimmune effects of …

Background Major depressive disorder is a serious psychiatric illness having serious
damaging effect on the quality of life of suffers. Quercetin is a plant flavonoid, mostly used as …

Ethnopharmacological relevance Cecropia pachystachya (CP) Trécul is a medicinal plant
native to South and Central America with several pharmacological properties, such as anti …

Flavonoids are phenolic compounds found commonly in plants that protect them against the
negative effects of environmental insults. These secondary metabolites have been widely …

Plant species of the genus Cecropia (Urticaceae) are used as traditional medicine in Latin-
America, and are commercially available as food supplements. The aim of this study was to …

Background: Many studies have been shown an important role of glutamatergic system as
well microglial activation in the pathophysiology of major depressive disorder (MDD). In …

Stress in early life has been appointed as an important phenomenon in the onset of
depression and poor response to treatment with classical antidepressants. Furthermore …