New trends in platinum and palladium complexes as antineoplastic agents
The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …
attention on the rational design of metal complexes that can be potentially used in cancer …
iCELLigence real‑time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines
L Türker Şener, G Albeni̇z… - Experimental and …, 2017 - spandidos-publications.com
The recently developed iCELLigence™ real‑time cell analyzer (RTCA) can be used for the
label‑free real‑time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity …
label‑free real‑time monitoring of cancer cell proliferation, viability, invasion and cytotoxicity …
Spatially dependent fluorescent probe for detecting different situations of mitochondrial membrane potential conveniently and efficiently
X Li, M Tian, GE Zhang, R Zhang, R Feng… - Analytical …, 2017 - ACS Publications
The feedback from mitochondrial membrane potential (MMP) in different situations (normal,
decreasing, and vanishing) can reflect different cellular status, which can be applied in …
decreasing, and vanishing) can reflect different cellular status, which can be applied in …
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
Background The outcome of triple negative breast cancer is still poor and requires
improvement with better therapy options. Autophagy has recently been shown to play a role …
improvement with better therapy options. Autophagy has recently been shown to play a role …
Recent advances in coordination chemistry of metal complexes based on nitrogen heteroaromatic alcohols. Synthesis, structures and potential applications
J Masternak, M Zienkiewicz-Machnik, M Kowalik… - Coordination Chemistry …, 2016 - Elsevier
This review is focused on the use of nitrogen-containing heteroaromatic alcohols as ligands
with increasing significance in diverse areas of chemistry. The application of such ligands …
with increasing significance in diverse areas of chemistry. The application of such ligands …
Effective platinum (IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria
H Chen, F Chen, W Hu, S Gou - Journal of inorganic biochemistry, 2018 - Elsevier
Platinum-based anticancer drugs are one of the most widely used anticancer
chemotherapeutics in oncology. Lonidamine (LND) could increase the response of human …
chemotherapeutics in oncology. Lonidamine (LND) could increase the response of human …
[HTML][HTML] Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration
MJ Nunes, AN Carvalho, C Sa-Lemos, M Colaco… - European Journal of …, 2024 - Elsevier
Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional
coactivators are key regulators of energy metabolism-related genes and are expressed in …
coactivators are key regulators of energy metabolism-related genes and are expressed in …
[HTML][HTML] Anticancer efficacies of arsenic disulfide through apoptosis induction, cell cycle arrest, and pro-survival signal inhibition in human breast cancer cells
Y Zhao, B Yuan, K Onda, K Sugiyama… - American journal of …, 2018 - ncbi.nlm.nih.gov
Arsenic disulfide, a major effective component of realgar, has been investigated for its anti-
cancer potential and shown to have therapeutic efficacies in hematological and some solid …
cancer potential and shown to have therapeutic efficacies in hematological and some solid …
Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells
Background It has been known epidermal growth factor receptor (EGFR) frequently
overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a …
overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a …
Platinum (IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance
X Huang, R Huang, S Gou, Z Wang, Z Liao… - Bioorganic & medicinal …, 2017 - Elsevier
Pt (IV) complexes comprising a phenstatin analogue, as dual-targeting Pt (IV) prodrug, were
designed and synthesized. They were found not only to carry the DNA binding platinum …
designed and synthesized. They were found not only to carry the DNA binding platinum …