[HTML][HTML] Sunlight damage to cellular DNA: Focus on oxidatively generated lesions
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …
of the most significant environmental DNA-damaging agents to which humans are exposed …
DNA oxidation and excision repair pathways
The physiological impact of the aberrant oxidation products on genomic DNA were
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …
DNA repair diseases: What do they tell us about cancer and aging?
The discovery of DNA repair defects in human syndromes, initially in xeroderma
pigmentosum (XP) but later in many others, led to striking observations on the association of …
pigmentosum (XP) but later in many others, led to striking observations on the association of …
Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins
Base and nucleotide excision repair (BER and NER) pathways are normally associated with
removal of specific types of DNA damage: small base modifications (such as those induced …
removal of specific types of DNA damage: small base modifications (such as those induced …
Glutathione depletion sensitizes cisplatin-and temozolomide-resistant glioma cells in vitro and in vivo
Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for
therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide …
therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide …
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations
SE Tsutakawa, AH Sarker, C Ng… - Proceedings of the …, 2020 - National Acad Sciences
Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA
damage responses (DDR) and a pathway coordinator and structure-specific endonuclease …
damage responses (DDR) and a pathway coordinator and structure-specific endonuclease …
Heterogeneity and overlaps in nucleotide excision repair disorders
D Ferri, D Orioli, E Botta - Clinical genetics, 2020 - Wiley Online Library
Nucleotide excision repair (NER) is an essential DNA repair pathway devoted to the removal
of bulky lesions such as photoproducts induced by the ultraviolet (UV) component of solar …
of bulky lesions such as photoproducts induced by the ultraviolet (UV) component of solar …
XPG: a multitasking genome caretaker
A Muniesa-Vargas, AF Theil, C Ribeiro-Silva… - Cellular and Molecular …, 2022 - Springer
The XPG/ERCC5 endonuclease was originally identified as the causative gene for
Xeroderma Pigmentosum complementation group G. Ever since its discovery, in depth …
Xeroderma Pigmentosum complementation group G. Ever since its discovery, in depth …
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells
LK Lerner, G Francisco, DT Soltys… - Nucleic acids …, 2017 - academic.oup.com
Genome lesions trigger biological responses that help cells manage damaged DNA,
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency
S Barnhoorn, LM Uittenboogaard, D Jaarsma… - PLoS …, 2014 - journals.plos.org
As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved
in repair of helix-distorting DNA lesions, but the protein has also been implicated in several …
in repair of helix-distorting DNA lesions, but the protein has also been implicated in several …