Since prehistory, human species have depended on plants for both food and medicine.
Even in countries with ready access to modern medicines, alternative treatments are still …

Despite significant advances in our understanding of the pathophysiology of multiple
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …

Purpose: Retinitis pigmentosa includes a group of progressive retinal degenerative
diseases that affect the structure and function of photoreceptors. Secondarily to the loss of …

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares
other retinal cells, leading to the hope that expression of light-activated signaling proteins in …

We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin
mutations in albino Sprague-Dawley (SD) rats. Three lines were generated with a proline to …

Leber hereditary optic neuropathy is due to mitochondrial DNA mutations; in∼ 70% of all
cases, a point mutation in the mitochondrial NADH dehydrogenase subunit 4, ND4, gene …

P23H rats express a variant of rhodopsin with a mutation that leads to loss of visual function
with similar properties as human autosomal dominant retinitis pigmentosa (RP). The …

The molecular mechanism of autosomal dominant retinitis pigmentosa (ADRP) in rats is
closely associated with a persistently activated unfolded protein response (UPR). If …

Baseline intracellular calcium levels are significantly higher in neuronal and glial cells of rat
retinas with retinitis pigmentosa (RP). Although this situation could initiate multiple …

KCNQ5 is suggestively associated with myopia, but its specific role in the myopic process
has not been studied further. The aim of this study was to investigate the expression of …