The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Polyphenolic antioxidants, including dietary plant lignans, modulate the gut–brain axis,
which involves transformation of these polyphenolic compounds into physiologically active …

Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …

The SARS-CoV-2 protease (3CLpro) is one of the key targets for the development of
efficacious drugs for COVID-19 treatment due to its essential role in the life cycle of the virus …

Flavonoids, a series of compounds with a C6-C3-C6 structure, mostly originate from plant
metabolism. Flavonoids have shown beneficial effects on many aspects of human …

Mulberry Diels–Alder-type adducts (MDAAs) are a group of rare natural polyphenols
biosynthetically derived from [4+ 2]-cycloaddition of chalcones and dehydroprenylphenols …

Pyran is a heterocyclic group containing oxygen that possesses a variety of pharmacological
effects. Pyran is also one of the most prevalent structural subunits in natural products, such …

The synthesis and biotransformation of five flavones containing methoxy substituents in the
B ring: 2′-, 3′-, 4′-methoxyflavones, 2′, 5′-dimethoxyflavone and 3′, 4′, 5 …

Rho‐associated coiled‐coil kinases (ROCKs) are key downstream effectors of small
GTPases. ROCK plays a central role in diverse cellular events with accumulating evidence …

A large series of 2-arylchromen-4-ones containing from 1 to 3 fluorine atoms or a
trifluoromethyl group in the structure was synthesized by condensation of fluorinated 2 …