Abstract Statins [3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase,
abbreviated HMGCR) inhibitors], are well-known cholesterol-depleting agents. Since the …

Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and
biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic, antitumor, and …

Background: Enhanced infiltration of M2-polarized tumor-associated macrophages (TAMs)
is linked to osteosarcoma (OS) metastasis and growth. Here, we aim to explore a novel miR …

Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children
and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the …

As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-
inducible protein that inhibits cytokine signaling in a variety of signaling pathways …

Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for
which are urgently needed. To identify such agents, we screened a panel of approved drugs …

Purpose The aims of this study were to determine the effect of curcumin on osteosarcoma
(OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic …

Recent scientific data recognize the B7-H3 checkpoint molecule as a potential target for
immunotherapy of pediatric solid tumors (PSTs). B7-H3 is highly expressed in extracranial …

Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby
responsible for most cellular physiological processes and their regulations. As for all …

Background Aggressive natural killer cell leukemia is a devastating disease, with an
average patient survival time of less than 2 months following diagnosis. Due to P …