Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review

MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

JC Bis, X Jian, BW Kunkle, Y Chen… - Molecular …, 2020 - nature.com
Abstract The Alzheimer's Disease Sequencing Project (ADSP) undertook whole exome
sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal …

The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer

G Huang, X Wu, S Li, X Xu, H Zhu, X Chen - Scientific reports, 2016 - nature.com
Recent evidence highlights the crucial regulatory roles of long noncoding RNAs (lncRNA) in
tumor biology. In colorectal cancer (CRC), the expression of several lncRNAs is …

The epigenetics of epilepsy and its progression

RM Hauser, DC Henshall, FD Lubin - The Neuroscientist, 2018 - journals.sagepub.com
Epilepsy is a common and devastating neurological disorder characterized by recurrent and
unprovoked spontaneous seizures. One leading hypothesis for the development and …

Epigenetic signaling and crosstalk in regulation of gene expression and disease progression

S Manna, J Mishra, T Baral, R Kirtana, P Nandi… - …, 2023 - Taylor & Francis
Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …

The epigenetics of the endocannabinoid system

R Meccariello, A Santoro, S D'Angelo… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological
tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing …

Developments in biological mechanisms and treatments for negative symptoms and cognitive dysfunction of schizophrenia

Q Wu, X Wang, Y Wang, YJ Long, JP Zhao… - Neuroscience Bulletin, 2021 - Springer
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction
in schizophrenia are the main issues attracting the attention of psychiatrists over the last …

The missing link: how exosomes and miRNAs can help in bridging psychiatry and molecular biology in the context of depression, bipolar disorder and schizophrenia

SK Gruzdev, AA Yakovlev, TA Druzhkova… - Cellular and Molecular …, 2019 - Springer
MicroRNAs (miRNAs) only recently have been recognized as promising molecules for both
fundamental and clinical neuroscience. We provide a literature review of miRNA biomarker …

LncRNA WTAPP1 promotes migration and angiogenesis of endothelial progenitor cells via MMP1 through microRNA 3120 and Akt/PI3K/autophagy pathways

WD Li, DM Zhou, LL Sun, L Xiao, Z Liu, M Zhou… - Stem Cells, 2018 - academic.oup.com
Efficient recruitment and angiogenesis of endothelial progenitor cells (EPCs) are critical
during a thrombus event. However, the details of EPC recruitment and the regulation of …