Abstract Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on
personal health and put an enormous burden on the healthcare system, and increasing …

Cognitive impairment is common in patients with cardiovascular disease. One in 3 patients
presenting at cardiology clinics have some degree of cognitive impairment, depending on …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Background: Emerging evidence suggests that elevated circulating levels of HDL-C (high-
density lipoprotein cholesterol) could be linked to an increased mortality risk. However, to …

Endothelial dysfunction represents a key mechanism underlying heart failure with preserved
ejection fraction (HFpEF), diabetes mellitus (DM), and frailty. However, reliable biomarkers …

Background Cardiac fibrosis represents a key element in the pathophysiology of heart
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …

Introduction While type 2 diabetes mellitus (T2DM) increases the risk of cardiac
complications, diabetes treatment choices may increase or decrease the rates of cardiac …

ABSTRACT Introduction Sodium Glucose co-Transporter 2 (SGLT2) inhibitors (also known
as 'gliflozins') represent a cornerstone to treat diabetes mellitus. Moreover, recent …

Background Hypertension is common in older adults and its incidence increases with age.
We investigated the correlation between physical and cognitive impairment in older adults …

As the world population ages, an expected increase in the prevalence of chronic kidney
disease (CKD) among older individuals will pose a considerable challenge for health care …