Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed
by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from …

Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Although dysfunction of mitochondria has …

Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …