Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets

R Sandireddy, VG Yerra, A Areti… - International journal …, 2014 - Wiley Online Library
In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation

Y Wu, L Ma, S Cai, Z Zhuang, Z Zhao, S Jin… - Signal transduction and …, 2021 - nature.com
The ongoing 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 has
posed a worldwide pandemic and a major global public health threat. The severity and …

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

A Asgarova, K Asgarov, Y Godet, P Peixoto… - …, 2018 - Taylor & Francis
Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased
capacities of proliferation, invasion and have the ability to generate metastases by escaping …

Macrophage polarization modulated by NF‐κB in polylactide membranes‐treated peritendinous adhesion

S Wang, M Lu, W Wang, S Yu, R Yu, C Cai, Y Li, Z Shi… - Small, 2022 - Wiley Online Library
Foreign body reactions (FBR) to implants seriously impair tissue‐implant integration and
postoperative adhesion. The macrophage, owing to its phenotypic plasticity, is a major …

Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms

PS Van Dam, MA Cotter, B Bravenboer… - European journal of …, 2013 - Elsevier
Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people
with diabetes, and are major risk factors for foot ulceration and amputation. The aetiology is …

Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes

G Negi, A Kumar, SS Sharma - Current neurovascular …, 2011 - ingentaconnect.com
High glucose driven reactive oxygen intermediates production and inflammatory damage
are recognized contributors of nerve dysfunction and subsequent damage in diabetic …

[HTML][HTML] Targeting neuroinflammation in distal symmetrical polyneuropathy in diabetes

ZZ Chong, DL Menkes, N Souayah - Drug discovery today, 2024 - Elsevier
Diabetic distal symmetric polyneuropathy is the most common type of peripheral neuropathy
complication of diabetes mellitus. Neuroinflammation is emerging as an important …

Activated microglia in the spinal cord underlies diabetic neuropathic pain

D Wang, R Couture, Y Hong - European journal of pharmacology, 2014 - Elsevier
Diabetes mellitus is an increasingly common chronic medical condition. Approximately 30%
of diabetic patients develop neuropathic pain, manifested as spontaneous pain …

SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for …

RP Joshi, G Negi, A Kumar, YB Pawar, B Munjal… - … , Biology and Medicine, 2013 - Elsevier
Curcumin has shown to be effective against various diabetes related complications.
However major limitation with curcumin is its low bioavailability. In this study we formulated …