Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …

The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that
undergoes numerous structural and compositional rearrangements that lead to the formation …

While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-
length isoform changes may better elucidate the functional consequences of these …

The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …

SF3b is a heptameric protein complex of the U2 small nuclear ribonucleoprotein (snRNP)
that is essential for pre-mRNA splicing. Mutations in the largest SF3b subunit …

Pladienolide is a naturally occurring antitumor macrolide that was discovered by using a cell-
based reporter gene expression assay controlled by the human vascular endothelial growth …

The genomes of most multicellular organisms contain a new class of introns that have non-
canonical consensus sequences. These minor-class introns occur extremely rarely and are …

Formation of catalytically active RNA structures within the spliceosome requires the
assistance of proteins. However, little is known about the number and nature of proteins …

Small molecule inhibitors that target components of the spliceosome have great potential as
tools to probe splicing mechanism and dissect splicing regulatory networks in cells. These …

The activated spliceosome (Bact) is in a catalytically inactive state and is remodeled into a
catalytically active machine by the RNA helicase Prp2, but the mechanism is unclear. Here …