Type 1 diabetes is an autoimmune disorder in which the immune system attacks and
destroys insulin-producing islet cells of the pancreas. Although islet transplantation has …

Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …

Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for
diabetes treatment,. However, this therapeutic strategy has not been systematically …

Decellularized (acellular) scaffolds, composed of natural extracellular matrix, form the basis
of an emerging generation of tissue-engineered organ and tissue replacements capable of …

摘要β 细胞补充治疗, 包括同种异体胰腺与胰岛移植, 对于脆性1 型糖尿病患者来说可使其
HbA1c 水平正常化, 但是供体短缺是个严重的问题. 为了克服这个问题, 异种移植是一种吸引人 …

The search for alternatives to allotransplants is driven by the shortage of corneal donors and
is demanding because of the limitations of the alternatives. Indeed, current progress in …

Even when well controlled—by frequent monitoring of blood glucose and administration of
insulin, the long-term complications of the disease are significant and include cardiovascular …

Repair of injured lungs represents a longstanding therapeutic challenge. We show that
human and mouse embryonic lung tissue from the canalicular stage of development (20–22 …

Xenotransplantation is one promising approach to bridge the gap between available human
cells, tissues, and organs and the needs of patients with diabetes or end‐stage organ …

Background Islet transplantation is an effective therapy for selected patients with type 1
diabetes with labile glycemic control and hypoglycemic unawareness, but donor organs are …