Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

The acquisition of cancer cell resistance to conventional chemotherapeutics is considered
the major driver of treatment failure and disease recurrence in most solid and hematological …

Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFRi) are
approved for treating EGFR-mutant lung adenocarcinoma (LUAD), emergence of acquired …

Background Neuroendocrine prostate cancer (NEPC) is a lethal subset of prostate cancer
which is characterized by neuroendocrine differentiation and loss of androgen receptor (AR) …

Receptor tyrosine kinases (RTKs) play a crucial role in cellular signaling and oncogenic
progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have …

Simple Summary The introduction of epidermal growth factor receptor (EGFR)-tyrosine
kinase inhibitors (TKIs) has revolutionized the treatment of lung cancer. Nevertheless, TKI …

Targeted therapy for malignancies has developed rapidly in recent years, benefiting patients
harboring genetic mutations sensitive to relevant tyrosine kinase inhibitors (TKIs). With the …

Epidermal growth factor receptor (EGFR) mutations are the most common oncogenic driver
in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase …

Chromatin is a vital and dynamic structure that is carefully regulated to maintain proper cell
homeostasis. A great deal of this regulation is dependent on histone proteins which have the …

Simple Summary This study investigated the relationship between erlotinib resistance and
stemness in lung adenocarcinoma. NCAPG2 was identified as an erlotinib resistance gene …