The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

Biomolecular associations forged by specific interaction among structural scaffolds are
fundamental to the control and regulation of cell processes. One such structural architecture …

In Drosophila melanogaster there are two genes encoding ribosomal protein S5, RpS5a and
RpS5b. Here, we demonstrate that RpS5b is required for oogenesis. Females lacking …

Translation is a fundamental step in gene expression that regulates multiple developmental
and stress responses. One key step of translation initiation is the association between eIF4E …

The evolutionary origin of eukaryotes spurred the transition from prokaryotic‐like translation
to a more sophisticated, eukaryotic translation. During this process, successive gene …

The conventional paradigm of translation initiation in eukaryotes states that the cap-binding
protein complex eIF4F (consisting of eIF4E, eIF4G and eIF4A) plays a central role in the …

In many eukaryotes, translation initiation is regulated by proteins that bind to the mRNA cap–
binding protein eukaryotic translation initiation factor 4E (eIF4E). These proteins commonly …

Germ cells use both positive and negative mRNA translational control to regulate gene
expression that drives their differentiation into gametes. mRNA translational control is …

The cap-binding translation initiation factor eIF4E (eukaryotic initiation factor 4E) is central to
protein synthesis in eukaryotes. As an integral component of eIF4F, a complex also …

Translation in eukaryotes is dependent on the activity of translation initiation factor (eIF) 4G
family of proteins, a scaffold protein that, during the initiation step, coordinates the activity of …