Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

MDA Paskeh, M Entezari, S Mirzaei, A Zabolian… - Journal of hematology & …, 2022 - Springer
Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

[HTML][HTML] Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

JH Lee, CD Mohan, A Deivasigamani, YY Jung… - Journal of Advanced …, 2020 - Elsevier
Introduction Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation
where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus …

Targeting CXCL12/CXCR4 axis in tumor immunotherapy

W Zhou, S Guo, M Liu, ME Burow… - Current medicinal …, 2019 - ingentaconnect.com
Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …

Targeting transcription factor STAT3 for cancer prevention and therapy

EZP Chai, MK Shanmugam, F Arfuso… - Pharmacology & …, 2016 - Elsevier
Abstract Signal Transducers and Activators of Transcription (STATs) comprise an important
class of transcription factors that have been implicated in a wide variety of essential cellular …

Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis

MK Shanmugam, KS Ahn, A Hsu, CC Woo… - Frontiers in …, 2018 - frontiersin.org
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated
with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in …

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

C Xu, H Zhao, H Chen, Q Yao - Drug design, development and …, 2015 - Taylor & Francis
Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are
involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G …

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

CD Mohan, S Rangappa, HD Preetham… - Seminars in cancer …, 2022 - Elsevier
Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …