Therapeutic proteins provide interventions for some of the most complex and intractable
diseases and are an essential part of modern medicine. Immunogenicity is the development …

Currently, there is a significant rise in the development and clinical use of a unique class of
pharmaceuticals termed as Biopharmaceuticals or Biologics, in the management of a range …

Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II
peptides presented to T-cells is crucial for designing innovative therapeutics against cancer …

Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a
crucial role in adaptive immunology, mediating the communication between T cells and …

The development of anti-drug antibodies (ADAs) following administration of biotherapeutics
to patients is a vexing problem that is attracting increasing attention from pharmaceutical …

Development of neutralizing antibodies against biotherapeutic agents administered to
prevent or treat various clinical conditions is a longstanding and growing problem faced by …

Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA)
class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated …

ABSTRACT TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein,
anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to …

Dendritic cells (DCs) are mediators between innate and adaptive immunity and vital in
initiating and modulating antigen-specific immune responses. The most important site for …

BACKGROUND: The uptake and processing of blood coagulation factor VIII (FVIII) by
antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4+ …