The scenario of paediatric acute myeloid leukaemia (AML), particularly non‐Down
syndrome acute megakaryoblastic leukaemia (non‐DS‐AMKL), has been recently …

This review aims to provide an overview of the current knowledge of the genetic lesions
driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and …

We report a novel NIPBL-NACC1 gene fusion in a rare primary hepatic neoplasm previously
described as the “cholangioblastic variant of intrahepatic cholangiocarcinoma.” The 2 index …

Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the
specific associations between age and phenotype. We observed that fusion oncogenes …

Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations
cause diverse pathologies, including leukemia. GATA-2-regulated enhancers increase …

The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in
infants and early childhood and is associated with dismal outcome. Here, we demonstrate …

Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL)
rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact …

Summary Meningioma-1 (MN1) overexpression in AML is associated with poor prognosis,
and forced expression of MN1 induces leukemia in mice. We sought to determine how MN1 …

Improvement in survival has been achieved for children and adolescents with AML but is
largely attributed to enhanced supportive care as opposed to the development of better …

Abstract CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic
leukemia that is associated with a poor prognosis. We establish a model of CBFA2T3-GLIS2 …