Immune targets for therapeutic development in depression: towards precision medicine
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
Bidirectional microglia–neuron communication in health and disease
Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
Neuroinflammation in bipolar depression
F Benedetti, V Aggio, ML Pratesi, G Greco… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Pathological mechanisms are still vastly unclear, and current treatments with conventional …
Early intervention in bipolar disorder
Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and
usually has its onset during youth. Its chronic course is associated with high rates of …
usually has its onset during youth. Its chronic course is associated with high rates of …
Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the …
In the 2011 “Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk
Reduction in Children and Adolescents,” several medical conditions among youth were …
Reduction in Children and Adolescents,” several medical conditions among youth were …
Inflamed moods: a review of the interactions between inflammation and mood disorders
Mood disorders have been recognized by the World Health Organization (WHO) as the
leading cause of disability worldwide. Notwithstanding the established efficacy of …
leading cause of disability worldwide. Notwithstanding the established efficacy of …
Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies
BACKGROUND: We conducted a meta-analysis of studies comparing cytokine
concentrations between patients with bipolar disorder (BD) and healthy control subjects …
concentrations between patients with bipolar disorder (BD) and healthy control subjects …
Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis
K Munkholm, JV Braüner, LV Kessing… - Journal of psychiatric …, 2013 - Elsevier
Background Bipolar disorder may be associated with peripheral immune system
dysfunction; however, results in individual studies are conflicting. Our aim was to …
dysfunction; however, results in individual studies are conflicting. Our aim was to …
[HTML][HTML] Inflammation, anxiety, and stress in bipolar disorder and borderline personality disorder: A narrative review
LF Saccaro, Z Schilliger, A Dayer, N Perroud… - Neuroscience & …, 2021 - Elsevier
Bipolar disorder (BD) and borderline personality disorder (BPD) are serious and prevalent
psychiatric diseases that share common phenomenological characteristics: symptoms (such …
psychiatric diseases that share common phenomenological characteristics: symptoms (such …
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated …
Background Immune dysfunction, including monocytosis and increased blood levels of
interleukin-1, interleukin-6 and tumour necrosis factor α has been observed during acute …
interleukin-1, interleukin-6 and tumour necrosis factor α has been observed during acute …