Progress on green crosslinking of polysaccharide hydrogels for drug delivery and tissue engineering applications

S Maiti, B Maji, H Yadav - Carbohydrate Polymers, 2024 - Elsevier
Natural polysaccharides are being studied for their biocompatibility, biodegradability, low
toxicity, and low cost in the fabrication of various hydrogel devices. However, due to their …

The versatility of squaramides: From supramolecular chemistry to chemical biology

LA Marchetti, LK Kumawat, N Mao, JC Stephens… - Chem, 2019 - cell.com
This review covers recent advances in the use of the squaramide moiety in chemical
research. We focus on the varied applications of squaramides under the broad headings of …

Comparative study of gelatin hydrogels modified by various cross-linking agents

J Skopinska-Wisniewska, M Tuszynska… - Materials, 2021 - mdpi.com
Gelatin is a natural biopolymer derived from collagen. Due to its many advantages, such as
swelling capacity, biodegradability, biocompatibility, and commercial availability, gelatin is …

Quinoline-based antimalarial hybrid compounds

S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2015 - Elsevier
Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

High‐Affinity Anion Binding by Steroidal Squaramide Receptors

SJ Edwards, H Valkenier, N Busschaert… - Angewandte …, 2015 - Wiley Online Library
Exceptionally powerful anion receptors have been constructed by placing squaramide
groups in axial positions on a steroidal framework. The steroid preorganizes the squaramide …

Squaramides as bioisosteres in contemporary drug design

KA Agnew-Francis, CM Williams - Chemical Reviews, 2020 - ACS Publications
Squaramides represent a class of vinylogous amides that are derived from the squarate
oxocarbon dianion. While they have been known since the 1950s, squaramides have only …

Squaric acid analogues in medicinal chemistry

J Chasák, V Šlachtová, M Urban, L Brulíková - European Journal of …, 2021 - Elsevier
In this review, we summarize the published data on squaric acid analogues with a special
focus on their use in medicinal chemistry and as potential drugs. Squaric acid is an …

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

MP Carrasco, AS Newton, L Gonçalves, A Góis… - European journal of …, 2014 - Elsevier
A library comprising 44 diversely substituted aurones derivatives was synthesized by
straightforward aldol condensation reactions of benzofuranones and the appropriately …

Synthesis and Biological Evaluation of N,N′-Squaramides with High in Vivo Efficacy and Low Toxicity: Toward a Low-Cost Drug against Chagas Disease

F Olmo, C Rotger, I Ramirez-Macias… - Journal of medicinal …, 2014 - ACS Publications
Access to basic drugs is a major issue in developing countries. Chagas disease caused by
Trypanosoma cruzi is a paradigmatic example of a chronic disease without an effective …

Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges

KK Roy - International Journal of Antimicrobial Agents, 2017 - Elsevier
Malaria is an infectious disease causing vast mortality and morbidity worldwide. Although
antimalarial drugs are effective in several parts of the world, there is a serious threat to …