Formation of the central nervous system requires a period of extensive progenitor cell
proliferation, accompanied or closely followed by differentiation; the balance between these …

Recent findings provide evidence for a functional interplay between DNA replication and the
seemingly distinct areas of cancer, development and pluripotency. Protein complexes …

The generation of multiciliated cells (MCC s) is required for the proper function of many
tissues, including the respiratory tract, brain, and germline. Defects in MCC development …

The intricate balance between proliferation and differentiation is of fundamental importance
in the development of the central nervous system (CNS). The division versus differentiation …

During reprogramming into human induced pluripotent stem cells (iPSCs), several stem cell
marker genes are induced, such as OCT-4, NANOG, SALL4, and TERT. OCT-4, NANOG …

The early steps of neural development in the vertebrate embryo are regulated by sets of
transcription factors that control the induction of proliferative, pluripotent neural precursors …

To ensure that the genetic material is accurately passed down to daughter cells during
mitosis, dividing cells must duplicate their chromosomes and centrosomes once and only …

Neural cell fate acquisition is mediated by transcription factors expressed in nascent
neuroectoderm, including Geminin and members of the Zic transcription factor family …

Molecular mechanisms governing maintenance, commitment, and differentiation of stem
cells are largely unexploited. Molecules involved in the regulation of multiple cellular …

Balancing stem cell self-renewal and initiation of lineage specification programs is essential
for the development and homeostasis of the hematopoietic system. We have specifically …