The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Background Radioresistance is a major factor leading to the failure of radiotherapy and poor
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …

Radiation therapy (RT) continues to be one of the mainstays of cancer treatment.
Considerable efforts have been recently devoted to integrating MRI into clinical RT planning …

Lactate generated from pyruvate fuels production of intracellular NAD+ as an end result of
the glycolytic process in tumors. Elevated lactate concentration represents a good indicator …

Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …

With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …