Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both
genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms …

Adult-onset Still's disease (AOSD) is a rare disease affecting multiple systems and organs
with unknown etiology, and the clinical symptoms are usually described as spiking fever …

A body of evidence has re‐energized the interest on the role neutrophils in inflammatory and
autoimmune conditions. For decades, neutrophils have been considered a homogenous …

Modulation of miRNAs and neutrophil extracellular traps (NETs) formation are both
implicated in inflammatory disorders. Adult-onset Still's disease (AOSD) is a systemic …

Neutrophils are innate immune phagocytes that play a key role in immune defense against
invading pathogens. The main offensive mechanisms of neutrophils are the phagocytosis of …

Neutrophils have both antimicrobial ability and pathogenic effect in the immune system,
neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their …

Systemic juvenile idiopathic arthritis (JIA) and adult-onset Still's disease (AOSD) are
systemic inflammatory disorders that manifest as high-spiking fever, joint pain, evanescent …

Low‐density granulocytes (LDGs), a distinct subset of neutrophils that colocalize with
peripheral blood mononuclear cells after density gradient centrifugation, have been …

Low density neutrophils (LDNs) are described in a number of inflammatory conditions,
cancers and infections and associated with immunopathology, and a mechanistic role in …

Systemic rheumatic diseases are a heterogeneous group of disorders characterized by
profound immune dysregulation. Recent discoveries have led to a significant resurgence of …