Fatty acids are essential for survival, acting as bioenergetic substrates, structural components and signalling molecules. Given their vital role, cells have evolved mechanisms …
Q Shi, Q Shen, Y Liu, Y Shi, W Huang, X Wang, Z Li… - Cancer cell, 2022 - cell.com
How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages (TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal immune cells of this organ. Microglial features are strongly dependent on environmental …
SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural components. The emerging field of …
A Szwed, E Kim, E Jacinto - Physiological reviews, 2021 - journals.physiology.org
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
M Li, Y Yang, L Xiong, P Jiang, J Wang, C Li - Journal of hematology & …, 2023 - Springer
Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug resistance by …
Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …