Acetyl-CoA metabolism in cancer

DA Guertin, KE Wellen - Nature Reviews Cancer, 2023 - nature.com
Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Lipogenesis inhibitors: therapeutic opportunities and challenges

B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Q Shi, Q Shen, Y Liu, Y Shi, W Huang, X Wang, Z Li… - Cancer cell, 2022 - cell.com
How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

LK Billingham, JS Stoolman, K Vasan… - Nature …, 2022 - nature.com
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

D Erny, N Dokalis, C Mezö, A Castoldi, O Mossad… - Cell Metabolism, 2021 - cell.com
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Regulation and metabolic functions of mTORC1 and mTORC2

A Szwed, E Kim, E Jacinto - Physiological reviews, 2021 - journals.physiology.org
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions

PS Liu, YT Chen, X Li, PC Hsueh, SF Tzeng… - Nature …, 2023 - nature.com
Exposure of lipopolysaccharide triggers macrophage pro-inflammatory polarization
accompanied by metabolic reprogramming, characterized by elevated aerobic glycolysis …

Metabolism, metabolites, and macrophages in cancer

M Li, Y Yang, L Xiong, P Jiang, J Wang, C Li - Journal of hematology & …, 2023 - Springer
Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Mitochondrial TCA cycle metabolites control physiology and disease

I Martínez-Reyes, NS Chandel - Nature communications, 2020 - nature.com
Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …