Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell
membranes. Here we report the development of a Salmonella-based intracellular delivery …

GSDMB is associated with several inflammatory diseases, such as asthma, sepsis and
colitis. GZMA is released by cytotoxic lymphocytes and cleaves GSDMB at the K244 site and …

Background Apoptosis is a form of programmed cell death that is regulated by the Bcl-2
family and caspase family of proteins. The caspase cascade responsible for executing cell …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Apoptosis is a complex multi-step process driven by caspase-dependent proteolytic
cleavage cascades. Dysregulation of apoptosis promotes tumorigenesis and limits the …

Background Zinc oxide nanoparticles (ZnO NPs) have received much attention for their
implications in cancer therapy. It has been reported that ZnO NPs induce selective killing of …

Summary Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization
of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via …