The molecular biology of phosphodiesterase 4 enzymes as pharmacological targets: an interplay of isoforms, conformational states, and inhibitors

D Paes, M Schepers, B Rombaut, D van den Hove… - Pharmacological …, 2021 - ASPET
The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of
the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …

[HTML][HTML] Recent advances in Forensic DNA Phenotyping of appearance, ancestry and age

M Kayser, W Branicki, W Parson, C Phillips - Forensic Science International …, 2023 - Elsevier
Abstract Forensic DNA Phenotyping (FDP) comprises the prediction of a person's externally
visible characteristics regarding appearance, biogeographic ancestry and age from DNA of …

[HTML][HTML] Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones

A Woźniak, A Heidegger, D Piniewska-Róg… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

An ELOVL2-based epigenetic clock for forensic age prediction: a systematic review

E Paparazzo, V Lagani, S Geracitano… - International Journal of …, 2023 - mdpi.com
The prediction of chronological age from methylation-based biomarkers represents one of
the most promising applications in the field of forensic sciences. Age-prediction models …

New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis

JT Brenna, KSD Kothapalli - Current Opinion in Clinical Nutrition & …, 2022 - journals.lww.com
The mixture of fatty acids available to FADS2 in any tissue defines the product mixture
available for further synthesis of membrane lipids and signaling molecules and may be …

Identifying methylation patterns in dental pulp aging: Application to age-at-death estimation in forensic anthropology

S C. Zapico, Q Gauthier, A Antevska… - International Journal of …, 2021 - mdpi.com
Age-at-death estimation constitutes one of the key parameters for identification of human
remains in forensic investigations. However, for applications in forensic anthropology, many …

A blood–bone–tooth model for age prediction in forensic contexts

H Correia Dias, L Manco, F Corte Real, E Cunha - Biology, 2021 - mdpi.com
Simple Summary DNA methylation age estimation is one of the hottest topics in forensic field
nowadays. Age estimation can be improved under a multidisciplinary approach, the role of a …

Pyrosequencing: Current forensic methodology and future applications—A review

M Ghemrawi, NF Tejero, G Duncan… - Electrophoresis, 2023 - Wiley Online Library
The recent development of small, single‐amplicon‐based benchtop systems for
pyrosequencing has opened up a host of novel procedures for applications in forensic …

Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications

J Naue - Genes & Genomics, 2023 - Springer
Background DNA analysis for forensic investigations has a long tradition with important
developments and optimizations since its first application. Traditionally, short tandem …

An interdisciplinary forensic approach for human remains identification and missing persons investigations

A Dahal, D McNevin, M Chikhani… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
The resolution of unidentified human remains (UHR) and long‐term missing persons (LTMP)
cases is paramount for administrative, legal, and humanitarian reasons. There are various …