BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Following embryo implantation, extravillous trophoblasts (EVTs) invade the maternal
decidua to a certain extent during early pregnancy, which is critical for normal placentation …

Exosomes are a subset of extracellular vesicles (EVs) that have important roles in
intercellular communication. They contain and carry bioactive molecules within their …

Context: Hyperglycemia and hypoxia are risk factors of metabolic complication during
pregnancy. The interactions between oxygen and glucose-sensing pathways that regulate …

The human placenta is a unique organ that performs the function of the majority of fetal
organs across gestation. How the placenta communicates with maternal tissues to prepare …

Background Extravillous trophoblast (EVT) cell invasion is a tightly regulated process that
requires for a normal pregnancy. The epithelial-mesenchymal transition (EMT) has been …

Obesity is now a worldwide epidemic. In recent years, different phenotypes of obesity,
ranging from metabolically healthy normal weight to metabolically unhealthy obese, were …

Objective To investigate the biological role of growth differentiation factor 8 (GDF8) in the
regulation of steroidogenesis in human granulosa-lutein (hGL) cells. Design Experimental …

Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and
was originally identified in the musculoskeletal system as a negative regulator of skeletal …

Myostatin (Mstn) is a skeletal muscle growth inhibitor involved in metabolic disorders and
heart fibrosis. In this study we sought to verify whether Mstn is also operative in …