Following the identification of several disease-associated polymorphisms by genome-wide
association (GWA) analysis, interest is now focusing on the detection of effects that, owing to …

Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

Currently, algorithms and softwares for genetic analysis of diploid organisms with bi-allelic
markers are well-established, while those for polyploids are limited. Here, we present …

The factors that determine the tempo and mode of protein evolution continue to be a central
question in molecular evolution. Traditionally, studies of protein evolution focused on the …

“A Mathematical Theory of Communication” was published in 1948 by Claude Shannon to
address the problems in the field of data compression and communication over (noisy) …

For complex diseases, the relationship between genotypes, environment factors, and
phenotype is usually complex and nonlinear. Our understanding of the genetic architecture …

Much of the natural variation for a complex trait can be explained by variation in DNA
sequence levels. As part of sequence variation, gene–gene interaction has been …

Association study (especially the genome-wide association study) now has a key function in
identification and characterization of disease-predisposing genetic variant (s), which …

Currently, most methods for detecting gene–gene interactions (GGIs) in genome-wide
association studies are divided into SNP-based methods and gene-based methods …

Alzheimer's disease affects millions of people worldwide and incidence is expected to rise
as the population ages, but no effective therapies exist despite decades of research and …