Revisiting the paraquat-induced sporadic Parkinson's disease-like model

S Bastías-Candia, JM Zolezzi, NC Inestrosa - Molecular neurobiology, 2019 - Springer
Parkinson's disease (PD) is a major neurodegenerative disorder that affects 1–2% of the
total global population. Despite its high prevalence and publication of several studies …

Drosophila melanogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components

K Panchal, AK Tiwari - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Plants/plant-derived components have been used from ancient times to treat/cure several
human diseases. Plants and their parts possess several chemical components that play the …

A CRISPR screen identifies a pathway required for paraquat-induced cell death

CR Reczek, K Birsoy, H Kong, I Martínez-Reyes… - Nature chemical …, 2017 - nature.com
Paraquat, a herbicide linked to Parkinson's disease, generates reactive oxygen species
(ROS), which causes cell death. Because the source of paraquat-induced ROS production …

Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner

BC Lee, HM Lee, S Kim, AS Avanesov, A Lee… - Scientific reports, 2018 - nature.com
Accumulation of oxidized amino acids, including methionine, has been implicated in aging.
The ability to reduce one of the products of methionine oxidation, free methionine-R …

Localization of lesion cells and targeted mitochondria via embedded hydrogel microsphere using heat transfer microneedles

F Lin, Y Zhuang, L Xiang, T Ye, Z Wang… - Advanced Functional …, 2023 - Wiley Online Library
The localization of lesion cells and targeted regulation of organelle function can promote the
lesion repair. However, conventional regulation is difficult to reach deep lesions and target …

Comparative transcriptome analysis of Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) reveals novel insights into heat stress tolerance in insects

Y Liu, H Su, R Li, X Li, Y Xu, X Dai, Y Zhou, H Wang - Bmc Genomics, 2017 - Springer
Background Heat tolerance is a key parameter that affects insect distribution and
abundance. Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) is a devastating pest of …

Innate immune responses to paraquat exposure in a Drosophila model of Parkinson's disease

U Maitra, MN Scaglione, S Chtarbanova… - Scientific reports, 2019 - nature.com
Parkinson's disease (PD) is a progressive, neurodegenerative movement disorder
characterized by the loss of dopaminergic (DA) neurons. Limited understanding of the early …

LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway

Y Xing, Y Liu, Z Qi, Z Liu, X Wang, H Zhang - Cellular & Molecular Biology …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) is now the second leading cause of cancer
death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and …

[HTML][HTML] Heat shock proteins: a therapeutic target worth to consider

A Dubey, KS Prajapati, M Swamy, V Pachauri - Veterinary world, 2015 - ncbi.nlm.nih.gov
Heat shock proteins (HSPs) are the molecular chaperones, that are not only expressed
during the normal growth process of cell cycle consecutively, but also get induced in cells …

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson's …

HS Chaouhan, X Li, KT Sun, IK Wang, TM Yu, SH Yu… - Antioxidants, 2022 - mdpi.com
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder with limited clinical treatments. The occurrence of PD includes both genetic and …