Exploring Nrf2 as a therapeutic target in testicular dysfunction

DE Rotimi, OA Ojo, TD Olaolu, OS Adeyemi - Cell and Tissue Research, 2022 - Springer
Testicular dysfunction, a major contributory factor to infertility, has received a lot of attention
over the recent years. Several studies have linked abnormal sperm function and morphology …

The role of toxic metals and metalloids in Nrf2 signaling

A Buha, K Baralić, D Djukic-Cosic, Z Bulat, A Tinkov… - Antioxidants, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance
to oxidants, serves as one of the key defensive factors against a range of pathological …

Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway

T Jin, C Chen - Food and Chemical Toxicology, 2022 - Elsevier
Background Ferroptosis is a novel form of lipid reactive oxygen species and iron dependent
cell death, and it has been shown to be involved in renal tubular injury in diabetic mice. Nrf2 …

7-hydroxycoumarin modulates Nrf2/HO-1 and microRNA-34a/SIRT1 signaling and prevents cisplatin-induced oxidative stress, inflammation, and kidney injury in rats

DH Sami, AS Soliman, AA Khowailed, EHM Hassanein… - Life Sciences, 2022 - Elsevier
The kidneys are vulnerable to toxicity and acute kidney injury (AKI) is the main adverse
effect associated with the clinical use of the chemotherapeutic agent cisplatin (CIS) …

[HTML][HTML] Umbelliferone prevents isoproterenol-induced myocardial injury by upregulating Nrf2/HO-1 signaling, and attenuating oxidative stress, inflammation, and cell …

OY Althunibat, MS Abduh, MH Abukhalil… - Biomedicine & …, 2022 - Elsevier
The role of oxidative injury and inflammatory response in cardiovascular diseases and heart
failure has been well-acknowledged. This study evaluated the protective effect of …

Vitamin D3 Protects Mice from Diquat‐Induced Oxidative Stress through the NF‐κB/Nrf2/HO‐1 Signaling Pathway

H Zhang, Y Liu, X Fang, L Gu, C Luo… - Oxidative medicine …, 2021 - Wiley Online Library
Vitamin D3, as an indispensable and fat‐soluble micronutrient, plays an important role in the
health of humans and animals. At present, studies are focusing on the calcium absorption …

Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of …

MM Ommati, HN Ahmadi, S Sabouri… - Environmental …, 2022 - Wiley Online Library
Lead (Pb) is a highly toxic heavy metal widely dispersed in the environment because of
human industrial activities. Many studies revealed that Pb could adversely affect several …

Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats

RS Alruhaimi - Environmental Science and Pollution Research, 2023 - Springer
The widespread application of organophosphorus (OP) pesticides can affect the
environment as well as the animal and human health. Chlorpyrifos (CPF) is a broad …

Lead toxicity and potential therapeutic effect of plant-derived polyphenols

C Niu, M Dong, Y Niu - Phytomedicine, 2023 - Elsevier
Background Due to its unique physical and chemical properties, lead is still used worldwide
in several applications, especially in industry. Both environmental and industrial lead …

Silymarin abrogates acrylamide‐induced oxidative stress‐mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and …

HA Alturki, HA Elsawy, AC Famurewa - Andrologia, 2022 - Wiley Online Library
Acrylamide (ACR) is a toxic chemical formed in foods processed at high temperature; it is a
food‐borne toxicant with increasing public health attention due to its carcinogenic …