Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Organoids are three‐dimensional (3D) cell culture systems that simulate the structures and
functions of organs, involving applications in disease modeling, drug screening, and cellular …

Human organoids allow the study of proliferation, lineage specification, and 3D tissue
development. Here we present a genome-wide CRISPR screen in induced pluripotent stem …

Purpose Organoids are three-dimensional cultures of stem cells in an environment similar to
the body's extracellular matrix. This is also a novel development in the realm of regenerative …

Background Hemolysis occurs in many injury settings and can trigger disease processes. In
the kidney, extracellular hemoglobin can induce damage via several mechanisms. These …

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With recent advances in the reprogramming of somatic cells into induced Pluripotent Stem
Cells (iPSCs), gene editing technologies, and protocols for the directed differentiation of …

Sepsis-induced acute kidney injury (S-AKI) is one of the most serious life-threatening
complications of sepsis. The pathogenesis of S-AKI is complex and there is no effective …

While up to 50% of children requiring kidney replacement therapy have congenital
anomalies of the kidney and urinary tract (CAKUT), they represent only a fraction of the total …

The formation, growth and maintenance of our organs, such as our kidneys or pancreas,
requires their coordinated growth alongside the intricate vasculature that pervades them …