Phosphodiesterase (PDE) is a superfamily of enzymes that are responsible for the
hydrolysis of two second messengers: cyclic adenosine monophosphate (cAMP) and cyclic …

Objectives This study examined the association between phosphodiesterase-5 inhibitor
(PDE-5i) use and outcomes in patients with contemporary centrifugal flow left ventricular …

Pulmonary hypertension (PH) due to left heart failure is becoming increasingly prevalent
and is associated with poor outcome. The precise pathophysiological mechanisms behind …

In addition to detrimental inflammation, widespread axon degeneration is an important
feature of multiple sclerosis (MS) pathology and a major correlate for permanent clinical …

Icariin, a major component of Epimedium species, was evaluated using isoproterenol (ISO)-
induced cardiotoxicity in Wistar rats. Rats were treated with icariin at the doses of 1, 5, and …

Background The goal was to examine the hemodynamic and clinical effects of long-term
therapy with PDE5 inhibitor sildenafil (SILD) in patients with advanced, pre-transplant heart …

Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and
pharmacological treatments that enhance this process will critically impact the long term …

At least 1 in 5 Canadians will experience heart failure (HF) during their lifetimes, with an
average 1-year mortality rate of 23.4%. Hospitalizations for HF are projected to increase 3 …

Background Severe pulmonary hypertension is a usual contraindication to heart
transplantation. A few studies have found that sildenafil has a favourable effect on …

Novel treatment of congestive heart failure (HF) involves utilizing unique pathways to
improve upon contemporary therapies. Increasing the availability of cyclic guanosine …