The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

ABSTRACT Thy‐1 (CD90) is a 25–37 kDa glyco‐sylphosphatidylinositol (GPI)‐anchored
glycoprotein expressed on many cell types, including T cells, thymocytes, neurons …

Fluid shear stress caused by blood flow is a major determinant of vascular remodeling and
arterial tone and can lead to development of atherosclerosis. The endothelial monolayer in …

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. In response to a brain injury, astrocytes …

Ischemic strokes (IS) and spinal cord injuries (SCI) are major causes of disability. RhoA is a
small GTPase protein that activates a downstream effector, ROCK. The up-regulation of the …

Thy-1 is a 25–37 kDa glycosylphosphatidylinositol (GPI)-anchored protein involved in T cell
activation, neurite outgrowth, apoptosis, tumor suppression, wound healing, and fibrosis. To …

Cross-talk between the major angiogenic growth factor, VEGF, and integrin cell adhesion
receptors has emerged recently as a critical factor in the regulation of angiogenesis and …

Migration and invasion are essential steps associated with tumor cell metastasis and
increasing evidence points towards endosome trafficking being essential in this process …

Background Neuroinflammation involves cytokine release, astrocyte reactivity and migration.
Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging α V β 3 Integrin and …