Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …

Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Obesity-related heart failure with preserved ejection fraction (HFpEF) has become a well-
recognized HFpEF subphenotype. Targeting the unfavorable cardiometabolic profile may …

BACKGROUND: The p. Arg14del variant of the PLN (phospholamban) gene causes
cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear …

Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …

Background Heart failure (HF) is the leading cause of morbidity and mortality worldwide, and
there is an urgent need for more global studies and data mining approaches to uncover its …

Cardiovascular diseases, including myocardial infarction (MI), constitute the leading cause
of morbidity and mortality worldwide. Protein-aggregate deposition is a hallmark of aging …

Genetic variants in α-actinin-2 (ACTN2) are associated with several forms of (cardio)
myopathy. We previously reported a heterozygous missense (c. 740C> T) ACTN2 gene …

While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of
numerous diseases, clinical approaches that ameliorate oxidative stress have been …

Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that
regulates cardiac contraction/relaxation by reversibly inhibiting the SERCA2a Ca2+ …