Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid beta (A)] and neurofibrillary tangles …

Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and
a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a …

Accumulating evidence points to an important role of intraneuronal Aβ as a trigger of the
pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's …

Mitochondria are important integrators of cellular function and therefore affect the
homeostatic balance of the cell. Besides their important role in producing adenosine …

Mitochondrial dysfunction and synaptic loss are among the earliest events linked to
Alzheimer's disease (AD) and might play a causative role in disease onset and progression …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and
behavioral dysfunction and is the leading cause of dementia in the elderly. Several studies …