Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

Background & Aims Macrophages contribute to liver disease, but their role in cholestatic
liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the …

Cholangiocyte senescence has been linked to primary sclerosing cholangitis (PSC).
Persistent secretion of growth factors by senescent cholangiocytes leads to the activation of …

Cholangiocytes are the epithelial cells that line the bile ducts. Along the biliary tree, two
different kinds of cholangiocytes exist: small and large cholangiocytes. Each type has …

The authors conducted a systematic review and meta-analysis to assess the effect of
antibiotic therapy in primary sclerosing cholangitis (PSC). Effect of antibiotic therapy on …

Abstract Background&Aims Primary sclerosing cholangitis (PSC) is characterized by chronic
inflammation and progressive fibrosis of the biliary tree. The bile acid receptor TGR5 is …

The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial
cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and …