Asthma is a heterogenous disease, and its prevalence and severity are different in males
versus females through various ages. As children, boys have an increased prevalence of …

Chronic obstructive pulmonary disease is mainly a smoking-related disorder and affects
millions of people worldwide, with a large effect on individual patients and society as a …

Airway remodeling comprises the structural changes of airway walls, induced by repeated
injury and repair processes. It is characterized by the changes of tissue, cellular, and …

Purpose Patients with severe eosinophilic asthma often experience recurrent asthma
exacerbations despite intensive inhaled corticosteroid therapy. In 2 previous double-blind …

This review article is a summary of a seminar organised by the European Respiratory
Society on “The role of small airways in obstructive airway diseases” which was held in …

Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but
the association between them is unclear. We assessed associations between blood …

For more than a century, clinicians have attempted to subdivide asthma into different
phenotypes based on triggers that cause asthma attacks, the course of the disease, or the …

Background Fixed airflow limitation can be found both in asthma and chronic obstructive
pulmonary disease (COPD), posing a day‐to‐day diagnostic challenge. Objective We aimed …

In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …