Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

Publisher Summary Lysyl oxidase (LOX) is a copper-containing amine oxidase belonging to
a heterogeneous family of enzymes that oxidize primary amine substrates to reactive …

NKX3. 1 is a prostatic tumor suppressor gene located on chromosome 8p. Although most
studies have shown that staining for NKX3. 1 protein is positive in the majority of primary …

Mouse models have provided significant insights into the molecular mechanisms of tumor
suppressor gene function. Here we use mouse models of prostate carcinogenesis to …

Polo-like kinase 3 (Plk3, previously termed Prk) contributes to regulation of M phase of the
cell cycle (Ouyang, B., Pan, H., Lu, L., Li, J., Stambrook, P., Li, B., and Dai, W.(1997) J. Biol …

Chromosomal deletion appears to be the earliest as well as the most frequent somatic
genetic alteration during carcinogenesis. It inactivates a tumor suppressor gene in three …

NKX3. 1 is a homeobox gene located at chromosome 8p21. 2, and one copy is frequently
deleted in prostate carcinoma. Prior studies of NKX3. 1 mRNA and protein in human …

Background The prevalence of carcinoma of the prostate gland (CaP) and high‐grade
prostatic intraepithelial neoplasia (HGPIN) was assessed in a Spanish population …

Gains in the long arm of chromosome 8 (8q) are believed to be associated with poor
outcome and the development of hormone-refractory prostate cancer. Based on a meta …