Shaping the cellular landscape with Set2/SETD2 methylation
SL McDaniel, BD Strahl - Cellular and Molecular Life Sciences, 2017 - Springer
Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set
during each round of transcription. Central to this process is the Set2/SETD2 …
during each round of transcription. Central to this process is the Set2/SETD2 …
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II
A Mayer, M Heidemann, M Lidschreiber, A Schreieck… - Science, 2012 - science.org
In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors
via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the …
via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the …
Updating the RNA polymerase CTD code: adding gene-specific layers
S Egloff, M Dienstbier, S Murphy - Trends in Genetics, 2012 - cell.com
The carboxyl-terminal domain (CTD) of RNA polymerase (pol) II comprises multiple tandem
repeats with the consensus sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 that can be …
repeats with the consensus sequence Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7 that can be …
The writers, readers, and functions of the RNA polymerase II C-terminal domain code
Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae
MA Ellison, S Namjilsuren, MK Shirra… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The Paf1 complex (Paf1C) is a conserved transcription elongation factor that
regulates transcription elongation efficiency, facilitates co-transcriptional histone …
regulates transcription elongation efficiency, facilitates co-transcriptional histone …
Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability
CLW Miller, JL Warner, F Winston - Trends in Genetics, 2023 - cell.com
Transcription elongation requires elaborate coordination between the transcriptional
machinery and chromatin regulatory factors to successfully produce RNA while preserving …
machinery and chromatin regulatory factors to successfully produce RNA while preserving …
Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast
CM DeGennaro, BH Alver, S Marguerat… - … and cellular biology, 2013 - Taylor & Francis
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA
polymerase II and histones to regulate gene expression. To gain a comprehensive …
polymerase II and histones to regulate gene expression. To gain a comprehensive …
Spt6 is required for the fidelity of promoter selection
Spt6 is a conserved factor that controls transcription and chromatin structure across the
genome. Although Spt6 is viewed as an elongation factor, spt6 mutations in Saccharomyces …
genome. Although Spt6 is viewed as an elongation factor, spt6 mutations in Saccharomyces …