Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Structure–activity relationships for ruthenium and osmium anticancer agents–towards clinical development

SM Meier-Menches, C Gerner, W Berger… - Chemical Society …, 2018 - pubs.rsc.org
Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

CC Konkankit, SC Marker, KM Knopf, JJ Wilson - Dalton Transactions, 2018 - pubs.rsc.org
The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Properties and applications of flavonoid metal complexes

MM Kasprzak, A Erxleben, J Ochocki - Rsc Advances, 2015 - pubs.rsc.org
Flavonoids are widely occurring polyphenol compounds of plant origin with multiple
biological and chemical activities. Due to the presence of carbonyl and hydroxyl groups they …

Challenges and opportunities in the development of organometallic anticancer drugs

CG Hartinger, N Metzler-Nolte, PJ Dyson - Organometallics, 2012 - ACS Publications
This review provides an introduction into the fascinating area of organometallic anticancer
compounds. Although the subject dates back many years, it has witnessed considerable …

Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

V Brabec, J Kasparkova - Coordination chemistry reviews, 2018 - Elsevier
Ruthenium complexes exhibit a broad variety of biological and biomedical activities
including anticancer efficiency. The reason is that the octahedral bonding of both Ru (II) and …

Applications of ruthenium complex in tumor diagnosis and therapy

K Lin, ZZ Zhao, HB Bo, XJ Hao, JQ Wang - Frontiers in Pharmacology, 2018 - frontiersin.org
Ruthenium complexes are a new generation of metal antitumor drugs that are currently of
great interest in multidisciplinary research. In this review article, we introduce the …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Opening the lid on piano-stool complexes: An account of ruthenium (II)–arene complexes with medicinal applications

AA Nazarov, CG Hartinger, PJ Dyson - Journal of Organometallic Chemistry, 2014 - Elsevier
Interest in the medicinal properties of ruthenium (II)–arene compounds has grown rapidly
over the last decade. In this account we describe the origins of the field and subsequently …

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

AK Renfrew - Metallomics, 2014 - academic.oup.com
The unique properties of transition metal complexes, such as environment-responsive
ligand exchange kinetics, diverse photochemical and photophysical properties, and the …