Colloidal systems based on lipids have attracted attention during the last two decades as a
delivery method of drugs that are poorly soluble in water. The investigations carried out have …

Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …

Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were designed as
exceptionally safe colloidal carriers for the delivery of poorly soluble drugs. SLN/NLC have …

In 1990, the lipid nanoparticles were invented in the laboratories, the first patent filings took
place in 1991. The lipid nanoparticles were developed as alternative to traditional carriers …

Formulations based on emulsions for enhancing hydrophobic and lipophilic drug delivery
and its bioavailability have attracted a lot of interest. As potential therapeutic agents, they are …

In the recent decades, various controlled delivery systems have been introduced with the
aim to improve solubility, stability and bioavailability of poorly absorbed drugs. Among all …

Ocular drug delivery remains challenging because of the complex nature and structure of
the eye. Conventional systems, such as eye drops and ointments, are inefficient, whereas …

The eye is a directly accessible sensitive organ, impairment of which causes direct effect on
the quality of life. Efficient ocular drug delivery remains a major challenge for the …

The objective of this study was to explore the potential of the nanostructured lipid carriers
(NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application …